MORPHOLOGICAL STUDIES OF
CALCAREOUS ALGAE PARTICLES FROM
GENRE LITHOTHANIUM SUBMITTED TO
SPRAY-DRYER
LOPES, F.C.1,2,3,PEREGRINO C.A.F.1,2,3; CORREA,T.S.P.1,2,3;MOURãO S.C.1,2,3; MOTTA, L.M.4;
SILVA, L.P.4
1 Laboratório de Desenvolvimento de Novas Formulações do Laboratório Universitário Rodolpho
Albino (LURA/EX); 2 Faculdade de Farmácia, Universidade Federal Fluminense(UFF); 3 Parque
Tecnológico da Vida/IVB; 4 Curso de Farmácia, Universidade Estadual da Zona Oeste (UEZO).
[email protected]
Keywords: calcareous algae, X-ray diffraction, spray dryer, scanning electron microscopy,
differential scanning calorimetry
Objetives: Perform morphological studies on calcareous algae particles from the genus
Lithothanium to evaluate your flow and compressibility behavior for the development of tablets
obtained by direct compression.
Methods: Was used the \\\"Willey\\\" type knife mill for initial crude sample trituration. Posteriorly,
proceeded with several washes, dilutions and successive filtrations to obtain 20% suspension (w / v)
in distilled water. The sample was subjected to spray drying equipment TECNAL LM MSD model 1.0,
using the spray nozzle with 1.3 mm aperture. Particle size analysis was performed on a
granulometric platform, following standard Brazilian Pharmacopoeia 5th Ed. The samples were
subjected to particle size analysis and scanning electron microscopy to characterize the shape and
size of the particles as well as X-ray diffraction and differential scanning calorimetry, for analyzing
of their crystallography.
Results: The sample subjected to particle size analysis showed a large amount of powder retained
in the collector after passing through the Tamils of 400 mesh, being a very fine powder according to
Brazilian Pharmacopoeia 5th Ed. This result was confirmed by the study of laser diffractometry
(particle Size Analyzer) where it was obtained a powder with a diameter around 0.038 mm. The
results of scanning electron microscopy showed a large amount of spherical particles of calcareous
algae different from those observed before the grinding process by colloid mill. Studies using
differential scanning calorimetry are still in process to confirm of the results obtained, as well as
studies of angle of repose and compressibility of the sample.
Acknowledgment: To the Instituto Vital Brazil for financial support and UEZO teachers