A FUNCTIONAL GLYCINE MODULATOR OF FUNCTIONAL ACTIVITY OF HUMAN
PHAGOCYTES IN COLOSTRUM
Paulo C. L. Guimarães, Cristiane C.C. P.Hara , Mércia A. G. Leite, Estéfani G. Souza, Gabriel
T. Nunes, Silvia H. B. Ratto, Rosa J. Volpato, Adenilda C.Honorio-França, Eduardo L. França.
Institute of Biosciences and Health - University Campus Araguaia - Federal University of Mato
Grosso. BR-070, 5 Km. Barra do Garças /MT-Brazil.
Glycine is formed of a carbon molecule linked to an amino group and carboxylic acid, have
cytoprotective effect, antiinflammatory and immunomodulating. The inflammatory reaction is
controlled by T-cells recognizing peptides of gluten, gliadin and glycine in the context of human
leukocyte antigen (HLA) molecules DQ2 and HLA-DQ8, which induces increase in intraepithelial
lymphocytes, villous atrophy and hyperplasia of the crypts . The functional food bioactive
organic compounds shows that play beneficial effects to health and reduce disease risk. In this
work we evaluated the action of glycine in phagocytosis, superoxide anion release and
microbicidal activity in the activation of cells in colostrum when adsorbed to polyethylene glycol.
Milk samples were obtained from 68 normal postpartum women enrolled in the health units of
the Herons Bar-MT. Obtaining phagocytes was performed by density gradient. To verify that the
cells are activated was analyzed superoxide anion release, phagocytosis and microbicidal
activity, the results were subjected to analysis of variance and were significant p <0.05. It was
observed that the colostrum of mononuclear phagocytes in the presence of polyethylene glycol
adsorbed glycine modulates the release of superoxide anion, and phagocytosis, microbicidal
activity. These results allow us to infer the adsorption of polyethylene glycol to glycine
modulates the cellular activity of phagocytes of human colostrum.